| UniProt Protein Function: | CDK7: a protein kinase of the CDK family. Forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). Activates the cyclin-associated kinases CDK1, -2, -4 and -6. An essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. Serves as a direct link between the regulation of transcription and the cell cycle. Phosphorylates and activates RNA polymerase II, allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| UniProt Protein Details: | Protein type:Protein kinase, CMGC; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cell cycle regulation; EC 2.7.11.23; EC 2.7.11.22; CMGC group; CDK family; CDK7 subfamily; CDK/CDK7 subfamily Chromosomal Location of Human Ortholog: 5q12.1 Cellular Component: cytoplasm; holo TFIIH complex; mitochondrion; nucleoplasm; nucleus Molecular Function:DNA-dependent ATPase activity; kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase subunit kinase activity Biological Process: cell cycle arrest; cell proliferation; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mRNA capping; nucleotide-excision repair, preincision complex assembly; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein kinase activity; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
| NCBI Summary: | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50613 |
| NCBI GenInfo Identifier: | 1705722 |
| NCBI Gene ID: | 1022 |
| NCBI Accession: | P50613.1 |
| UniProt Secondary Accession: | P50613,Q9BS60, Q9UE19, |
| UniProt Related Accession: | P50613 |
| Molecular Weight: | 39,038 Da |
| NCBI Full Name: | Cyclin-dependent kinase 7 |
| NCBI Synonym Full Names: | cyclin dependent kinase 7 |
| NCBI Official Symbol: | CDK7Â Â |
| NCBI Official Synonym Symbols: | CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15Â Â |
| NCBI Protein Information: | cyclin-dependent kinase 7 |
| UniProt Protein Name: | Cyclin-dependent kinase 7 |
| UniProt Synonym Protein Names: | 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK7Â Â |
| UniProt Entry Name: | CDK7_HUMAN |
