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Anti-CEP164 Antibody (CAB9964)

SKU:
CAB9964
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
  • Cell Cycle Antibodies 2 Anti-CEP164 Antibody CAB9964
€139 - €419
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Description

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Antibody Name:Anti-CEP164 Antibody
Antibody SKU:CAB9964
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 730-829 of human CEP164 (NP_055771.4).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A375
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 730-829 of human CEP164 (NP_055771.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EASE KSEQ AALN AAKE KALQ QLRE QLEG ERKE AVAT LEKE HSAE LERL CSSL EAKH REVV SSLQ KKIQ EAQQ KEEA QLQK CLGQ VEHR VHQK SYHV AGYE
Gene ID:22897
Uniprot:Q9UPV0
Cellular Location:Cytoplasm, Nucleus, centriole, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:163kDa/164kDa
Observed MW:164kDa
Synonyms:CEP164, NPHP15
Background:This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CEP164: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. Defects in CEP164 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: centriole; centrosome; cytosol; extracellular space; nucleoplasm

Molecular Function:protein binding

Biological Process: cilium biogenesis; G2/M transition of mitotic cell cycle

Disease: Nephronophthisis 15

NCBI Summary:This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:Q9UPV0
NCBI GenInfo Identifier:162416241
NCBI Gene ID:22897
NCBI Accession:Q9UPV0.3
UniProt Secondary Accession:Q9UPV0,Q6PKH9, Q7Z2X9, Q9NVS0, Q9UFJ6,
UniProt Related Accession:Q9UPV0
Molecular Weight:163,544 Da
NCBI Full Name:Centrosomal protein of 164 kDa
NCBI Synonym Full Names:centrosomal protein 164
NCBI Official Symbol:CEP164  
NCBI Official Synonym Symbols:NPHP15  
NCBI Protein Information:centrosomal protein of 164 kDa
UniProt Protein Name:Centrosomal protein of 164 kDa
Protein Family:Centrosomal protein
UniProt Gene Name:CEP164  
UniProt Entry Name:CE164_HUMAN
Anti-CEP164 Polyclonal Antibody (CAB9964)Western blot analysis of extracts of A-375 cells, using CEP164 Antibody (CAB9964) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CEP164 Polyclonal Antibody (CAB9964)Immunohistochemistry of paraffin-embedded mouse brain using CEP164 antibody (CAB9964) (40x lens).
Anti-CEP164 Polyclonal Antibody (CAB9964)Immunohistochemistry of paraffin-embedded rat liver using CEP164 antibody (CAB9964) (40x lens).
Anti-CEP164 Polyclonal Antibody (CAB9964)Immunohistochemistry of paraffin-embedded rat heart using CEP164 antibody (CAB9964) (40x lens).
Anti-CEP164 Polyclonal Antibody (CAB9964)Immunohistochemistry of paraffin-embedded human liver damage using CEP164 antibody (CAB9964) (40x lens).

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