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Anti-CSN2 Antibody (CAB12749)

SKU:
CAB12749
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-CSN2 Antibody
Antibody SKU:CAB12749
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSN2 (NP_001882.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSN2 (NP_001882.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKVL ILAC LVAL ALAR ETIE SLSS SEES ITEY KQKV EKVK HEDQ QQGE DEHQ DKIY PSFQ PQPL IYPF VEPI PYGF LPQN ILPL AQPA VVLP VPQP EIME
Gene ID:1447
Uniprot:P05814
Cellular Location:Secreted
Calculated MW:25kDa
Observed MW:30kDa
Synonyms:CSN2, CASB
Background:This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CSN2: Important role in determination of the surface properties of the casein micelles. Belongs to the beta-casein family.
UniProt Protein Details:

Protein type:Calcium-binding; Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function:calcium ion binding; cysteine protease inhibitor activity; enzyme inhibitor activity

Biological Process: calcium ion transport; lactation

NCBI Summary:This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:P05814
NCBI GenInfo Identifier:115661
NCBI Gene ID:1447
NCBI Accession:P05814.4
UniProt Secondary Accession:P05814,Q4VAZ9, Q9UCM5,
UniProt Related Accession:P05814
Molecular Weight:25kDa
NCBI Full Name:Beta-casein
NCBI Synonym Full Names:casein beta
NCBI Official Symbol:CSN2  
NCBI Official Synonym Symbols:CASB  
NCBI Protein Information:beta-casein
UniProt Protein Name:Beta-casein
Protein Family:COP9 signalosome complex
UniProt Gene Name:CSN2  
Anti-CSN2 Antibody (CAB12749)Western blot analysis of extracts of MCF7 cells, using CSN2 antibody (CAB12749) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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