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Anti-CX3CR1 Antibody (CAB2890)

SKU:
CAB2890
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-CX3CR1 Antibody
Antibody SKU:CAB2890
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CX3CR1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse fetal muscle
Immunogen:A synthetic peptide of human CX3CR1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1524
Uniprot:P49238
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:40kDa/41kDa/43kDa
Observed MW:55kDa
Synonyms:CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
Background:Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
UniProt Protein Function:CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Receptor, cytokine; GPCR, family 1; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: neuron projection; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; negative regulation of cell migration; macrophage chemotaxis; microglial cell activation during immune response

Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:P49238
NCBI GenInfo Identifier:1351394
NCBI Gene ID:1524
NCBI Accession:P49238.1
UniProt Secondary Accession:P49238,A0N0N6, B2R5Z4, J3KP17,
UniProt Related Accession:P49238
Molecular Weight:43,969 Da
NCBI Full Name:CX3C chemokine receptor 1
NCBI Synonym Full Names:chemokine (C-X3-C motif) receptor 1
NCBI Official Symbol:CX3CR1  
NCBI Official Synonym Symbols:V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1  
NCBI Protein Information:CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1
UniProt Protein Name:CX3C chemokine receptor 1
UniProt Synonym Protein Names:Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
Protein Family:CX3C chemokine receptor
UniProt Gene Name:CX3CR1  
UniProt Entry Name:CX3C1_HUMAN
Anti-CX3CR1 Antibody (CAB2890)Western blot analysis of extracts of mouse fetal muscle, using CX3CR1 antibody (CAB2890). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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