The DAZ2 Polyclonal Antibody (CAB7600) is a versatile tool for researchers studying DAZ2, a gene involved in male germ cell development. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the DAZ2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations into reproductive biology and male infertility.DAZ2 is a key player in spermatogenesis and is essential for the production of healthy sperm.
Dysregulation of DAZ2 has been linked to male infertility and other reproductive disorders. By understanding the function of DAZ2, scientists can gain insights into the mechanisms underlying these conditions and potentially develop new therapies to address them.Overall, the DAZ2 Polyclonal Antibody (CAB7600) offers researchers a reliable tool for studying male germ cell development and advancing our understanding of reproductive health. Its specificity, sensitivity, and versatility make it a valuable asset in the field of reproductive biology.
Product Name:
DAZ2 Rabbit Polyclonal Antibody
SKU:
CAB7600
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DAZ2 (NP_001005785.1).
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
57055
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse testis, using DAZ2 antibody (CAB7600) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
