DNASE2 Antibody (PACO08900)
- SKU:
- PACO08900
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | DNASE2 Antibody (PACO08900) |
| Antibody SKU: | PACO08900 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human DNASE2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | deoxyribonuclease II, lysosomal;DNASE2;DNASE2A;DNL;DNL2 ; |
| UniProt Protein Function: | DNASE2: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family.Protein type: EC 3.1.22.1; DeoxyribonucleaseChromosomal Location of Human Ortholog: 19p13.2Cellular Component: lysosome; intracellularMolecular Function: DNA binding; deoxyribonuclease II activityBiological Process: erythrocyte differentiation; DNA fragmentation during apoptosis; DNA metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00115 |
| NCBI GenInfo Identifier: | 3182984 |
| NCBI Gene ID: | 1777 |
| NCBI Accession: | O00115.2 |
| UniProt Secondary Accession: | O00115,O43910, B2RD06 |
| UniProt Related Accession: | O00115 |
| Molecular Weight: | 39,581 Da |
| NCBI Full Name: | Deoxyribonuclease-2-alpha |
| NCBI Synonym Full Names: | deoxyribonuclease II, lysosomal |
| NCBI Official Symbol: | DNASE2Â Â |
| NCBI Official Synonym Symbols: | DNL; DNL2; DNASE2AÂ Â |
| NCBI Protein Information: | deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha |
| UniProt Protein Name: | Deoxyribonuclease-2-alpha |
| UniProt Synonym Protein Names: | Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2 |
| Protein Family: | Deoxyribonuclease |
| UniProt Gene Name: | DNASE2Â Â |
| UniProt Entry Name: | DNS2A_HUMAN |
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