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Anti-EXOSC5 Antibody (CAB15870)

SKU:
CAB15870
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

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Antibody Name:Anti-EXOSC5 Antibody
Antibody SKU:CAB15870
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human EXOSC5 (NP_064543.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human EXOSC5 (NP_064543.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEE THTD AKIR AENG TGSS PRGP GCSL RHFA CEQN LLSR PDGS ASFL QGDT SVLA GVYG PAEV KVSK EIFN KATL EVIL RPKI GLPG VAEK SRER LIRN TCEA VVLG TLHP RTSI TVVL QVVS DAGS LLAC CLNA ACMA LVDA GVPM RALF CGVA CALD SDGT LVLD PTSK QEKE ARAV LTFA LDSV ERKL LMSS TKGL YSDT ELQQ CLAA AQAA SQHV FRFY RESL QRRY SKS
Gene ID:56915
Uniprot:Q9NQT4
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:25kDa
Observed MW:25kDa
Synonyms:EXOSC5, RRP41B, RRP46, Rrp46p, hRrp46p, p12B
Background:
UniProt Protein Function:EXOSC5: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.
UniProt Protein Details:

Protein type:Ribonuclease; Nucleolus; EC 3.1.13.-

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol

Molecular Function:protein binding; 3'-5'-exoribonuclease activity; exoribonuclease activity; RNA binding

Biological Process: gene expression; DNA deamination; defense response to virus; rRNA processing; mRNA catabolic process, deadenylation-dependent decay

UniProt Code:Q9NQT4
NCBI GenInfo Identifier:14285757
NCBI Gene ID:56915
NCBI Accession:Q9NQT4.1
UniProt Related Accession:Q9NQT4
Molecular Weight:Calculated: 25kDaObserved: 25kDa
NCBI Full Name:Exosome complex component RRP46
NCBI Synonym Full Names:exosome component 5
NCBI Official Symbol:EXOSC5  
NCBI Official Synonym Symbols:p12B; RRP46; RRP41B; Rrp46p; hRrp46p  
NCBI Protein Information:exosome complex component RRP46
UniProt Protein Name:Exosome complex component RRP46
UniProt Synonym Protein Names:Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
Protein Family:Exosome complex component
UniProt Gene Name:EXOSC5  
UniProt Entry Name:EXOS5_HUMAN
Anti-EXOSC5 Antibody (CAB15870)Western blot analysis of extracts of rat pancreas, using EXOSC5 antibody (CAB15870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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