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Anti-GIMAP5 Antibody (CAB8684)

SKU:
CAB8684
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-GIMAP5 Antibody
Antibody SKU:CAB8684
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 190-270 of human GIMAP5 (NP_060854.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse kidney, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 190-270 of human GIMAP5 (NP_060854.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WGSV EEQR QQQA ELLA VIER LGRE REGS FHSN DLFL DAQL LQRT GAGA CQED YRQY QAKV EWQV EKHK QELR ENES NWAY K
Gene ID:55340
Uniprot:Q96F15
Cellular Location:Lysosome, Mitochondrion outer membrane, Single-pass type IV membrane protein
Calculated MW:34kDa/39kDa
Observed MW:34kDa
Synonyms:GIMAP5, HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD
Background:This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.
UniProt Protein Function:GIMAP5: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence. Belongs to the IAN GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Apoptosis; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: mitochondrial outer membrane; lysosome; integral to membrane

Molecular Function:GTP binding

NCBI Summary:This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96F15
NCBI GenInfo Identifier:28416949
NCBI Gene ID:55340
NCBI Accession:NP_060854.2
UniProt Secondary Accession:Q96F15,Q6IA75, Q96NE4, Q9NUK9, D3DWZ5,
UniProt Related Accession:Q96F15
Molecular Weight:34,846 Da
NCBI Full Name:GTPase IMAP family member 5
NCBI Synonym Full Names:GTPase, IMAP family member 5
NCBI Official Symbol:GIMAP5  
NCBI Official Synonym Symbols:IAN4; IAN5; IROD; IAN-5; IMAP3; HIMAP3; IAN4L1  
NCBI Protein Information:GTPase IMAP family member 5; immunity associated protein 3; immune associated nucleotide 4 like 1; immunity-associated nucleotide 5 protein; inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
UniProt Protein Name:GTPase IMAP family member 5
UniProt Synonym Protein Names:Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3
Protein Family:GTPase IMAP family
UniProt Gene Name:GIMAP5  
UniProt Entry Name:GIMA5_HUMAN
Anti-GIMAP5 Polyclonal Antibody (CAB8684)Western blot analysis of extracts of various cell lines, using GIMAP5 antibody (CAB8684) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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