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Anti-GSK3Beta Antibody (CAB16868)

SKU:
CAB16868
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-GSK3Beta Antibody CAB16868
  • Cell Biology Antibodies 7 Anti-GSK3Beta Antibody CAB16868
€139 - €419
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Description

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Antibody Name:Anti-GSK3Beta Antibody
Antibody SKU:CAB16868
Antibody Size:20uL, 50uL, 100uL
Application:WB IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human GSK3Beta.
Application:WB IP
Recommended Dilution:WB 1:500 - 1:2000 IP 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, LO2, mouse thymus, mouse testis, rat brain
Immunogen:Recombinant protein of human GSK3Beta.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2932
Uniprot:P49841
Cellular Location:Cell membrane, Cytoplasm, Nucleus
Calculated MW:46kDa/48kDa
Observed MW:47kDa
Synonyms:GSK3B, gsk-3Beta
Background:The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
UniProt Protein Function:GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation
UniProt Protein Details:

Protein type:Protein kinase, CMGC; EC 2.7.11.26; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: axon; beta-catenin destruction complex; cell soma; centrosome; cytoplasm; cytosol; dendritic shaft; dendritic spine; growth cone; lipid raft; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; ribonucleoprotein complex

Molecular Function:ATP binding; beta-catenin binding; integrin binding; ionotropic glutamate receptor binding; kinase activity; NF-kappaB binding; p53 binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; ubiquitin protein ligase binding

Biological Process: aging; axonogenesis; cell migration; circadian rhythm; dopamine receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; fat cell differentiation; genetic imprinting; glycogen metabolic process; hippocampus development; myoblast fusion; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of glycogen biosynthetic process; negative regulation of MAP kinase activity; negative regulation of neuron maturation; negative regulation of NFAT protein import into nucleus; negative regulation of nitric-oxide synthase activity; negative regulation of protein binding; negative regulation of protein complex assembly; organ morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of axon extension; positive regulation of cell-matrix adhesion; positive regulation of GTPase activity; positive regulation of neuron apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein export from nucleus; re-entry into mitotic cell cycle; regulation of microtubule-based process; regulation of neuronal synaptic plasticity; response to activity; response to drug; response to estradiol stimulus; response to insulin stimulus; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

NCBI Summary:The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P49841
NCBI GenInfo Identifier:20455502
NCBI Gene ID:2932
NCBI Accession:P49841.2
UniProt Secondary Accession:P49841,Q9BWH3, Q9UL47, D3DN89,
UniProt Related Accession:P49841
Molecular Weight:48,034 Da
NCBI Full Name:Glycogen synthase kinase-3 beta
NCBI Synonym Full Names:glycogen synthase kinase 3 beta
NCBI Official Symbol:GSK3B  
NCBI Protein Information:glycogen synthase kinase-3 beta
UniProt Protein Name:Glycogen synthase kinase-3 beta
UniProt Synonym Protein Names:Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
Protein Family:Glycogen synthase kinase
UniProt Gene Name:GSK3B  
UniProt Entry Name:GSK3B_HUMAN
Anti-GSK3Beta Antibody (CAB16868)Western blot analysis of extracts of various cell lines, using GSK3b antibody (CAB16868) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
Anti-GSK3Beta Antibody (CAB16868)Immunoprecipitation analysis of 200ug extracts of LO2 cells using 3ug GSK3b antibody (CAB16868). Western blot was performed from the immunoprecipitate using GSK3b antibody (CAB16868) at a dilition of 1:1000.

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