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Anti-IFNAR2 Antibody (CAB1769)

SKU:
CAB1769
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-IFNAR2 Antibody CAB1769
  • Cell Biology Antibodies 7 Anti-IFNAR2 Antibody CAB1769
  • Cell Biology Antibodies 7 Anti-IFNAR2 Antibody CAB1769
€139 - €419
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Description

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Antibody Name:Anti-IFNAR2 Antibody
Antibody SKU:CAB1769
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-243 of human IFNAR2 (NP_997467.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Raji, HepG2, THP-1, SW480, A-549, HeLa, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-243 of human IFNAR2 (NP_997467.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ISYD SPDY TDES CTFK ISLR NFRS ILSW ELKN HSIV PTHY TLLY TIMS KPED LKVV KNCA NTTR SFCD LTDE WRST HEAY VTVL EGFS GNTT LFSC SHNF WLAI DMSF EPPE FEIV GFTN HINV MVKF PSIV EEEL QFDL SLVI EEQS EGIV KKHK PEIK GNMS GNFT YIID KLIP NTNY CVSV YLEH SDEQ AVIK SPLK CTLL PPGQ ESES AESA K
Gene ID:3455
Uniprot:P48551
Cellular Location:Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:27kDa/37kDa/57kDa
Observed MW:58kDa
Synonyms:IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Background:The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
UniProt Protein Function:IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function:protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To

NCBI Summary:The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P48551
NCBI GenInfo Identifier:1352466
NCBI Gene ID:3455
NCBI Accession:P48551.1
UniProt Secondary Accession:P48551,Q15467, Q6FHD7, A8KAJ4, D3DSE8, D3DSE9,
UniProt Related Accession:P48551
Molecular Weight:515
NCBI Full Name:Interferon alpha/beta receptor 2
NCBI Synonym Full Names:interferon (alpha, beta and omega) receptor 2
NCBI Official Symbol:IFNAR2  
NCBI Official Synonym Symbols:IFN-R; IFNABR; IFNARB; IFN-alpha-REC  
NCBI Protein Information:interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain
UniProt Protein Name:Interferon alpha/beta receptor 2
UniProt Synonym Protein Names:Interferon alpha binding protein; Type I interferon receptor 2
UniProt Gene Name:IFNAR2  
UniProt Entry Name:INAR2_HUMAN
Anti-IFNAR2 Antibody (CAB1769)Western blot analysis of extracts of various cell lines, using IFNAR2 antibody (CAB1769) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-IFNAR2 Antibody (CAB1769)Immunohistochemistry of paraffin-embedded human colon carcinoma using IFNAR2 antibody (CAB1769) at dilution of 1:100 (40x lens).
Anti-IFNAR2 Antibody (CAB1769)Immunofluorescence analysis of U2OS cells using IFNAR2 antibody (CAB1769). Blue: DAPI for nuclear staining.

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