| UniProt Protein Function: | KCNIP4: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Belongs to the recoverin family. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4p15.32Cellular Component: cytoplasm; cytosol; plasma membrane; voltage-gated potassium channel complexMolecular Function: calcium ion binding; potassium channel regulator activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6PIL6 |
| NCBI GenInfo Identifier: | 73621129 |
| NCBI Gene ID: | 80333 |
| NCBI Accession: | Q6PIL6.1 |
| UniProt Secondary Accession: | Q6PIL6,Q3YAB8, Q3YAB9, Q3YAC0, Q3YAC1, Q3YAC2, Q4W5G8 Q8NEU0, Q9BWT2, Q9H294 |
| UniProt Related Accession: | Q6PIL6 |
| Molecular Weight: | 26,267 Da |
| NCBI Full Name: | Kv channel-interacting protein 4 |
| NCBI Synonym Full Names: | potassium voltage-gated channel interacting protein 4 |
| NCBI Official Symbol: | KCNIP4Â Â |
| NCBI Official Synonym Symbols: | CALP; KCHIP4Â Â |
| NCBI Protein Information: | Kv channel-interacting protein 4 |
| UniProt Protein Name: | Kv channel-interacting protein 4 |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 4; Calsenilin-like protein |
| Protein Family: | Kv channel-interacting protein |
| UniProt Gene Name: | KCNIP4Â Â |
| UniProt Entry Name: | KCIP4_HUMAN |
