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Anti-Lipocalin-1 Antibody (CAB9828)

SKU:
CAB9828
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-Lipocalin-1 Antibody CAB9828
  • Signal Transduction Antibodies 3 Anti-Lipocalin-1 Antibody CAB9828
€139 - €419
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Description

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Antibody Name:Anti-Lipocalin-1 Antibody
Antibody SKU:CAB9828
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-176 of human LCN1 (NP_002288.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:HL-60, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-176 of human LCN1 (NP_002288.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HHLL ASDE EIQD VSGT WYLK AMTV DREF PEMN LESV TPMT LTTL EGGN LEAK VTML ISGR CQEV KAVL EKTD EPGK YTAD GGKH VAYI IRSH VKDH YIFY CEGE LHGK PVRG VKLV GRDP KNNL EALE DFEK AAGA RGLS TESI LIPR QSET CSPG SD
Gene ID:3933
Uniprot:P31025
Cellular Location:Secreted
Calculated MW:19kDa
Observed MW:16kDa
Synonyms:LCN1, PMFA, TLC, TP, VEGP
Background:This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9.
UniProt Protein Function:LCN1: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular space; extracellular region

Molecular Function:cysteine protease inhibitor activity

Biological Process: long-chain fatty acid transport; retinal homeostasis; sensory perception of taste; response to stimulus; proteolysis; transmembrane transport

NCBI Summary:This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]
UniProt Code:P31025
NCBI GenInfo Identifier:401346
NCBI Gene ID:3933
NCBI Accession:P31025.1
UniProt Related Accession:P31025
Molecular Weight:
NCBI Full Name:Lipocalin-1
NCBI Synonym Full Names:lipocalin 1
NCBI Official Symbol:LCN1  
NCBI Official Synonym Symbols:TP; TLC; PMFA; VEGP  
NCBI Protein Information:lipocalin-1
UniProt Protein Name:Lipocalin-1
UniProt Synonym Protein Names:Tear lipocalin; Tlc; Tear prealbumin; TP; Von Ebner gland protein
Protein Family:Lipocalin
UniProt Gene Name:LCN1  
UniProt Entry Name:LCN1_HUMAN
Anti-Lipocalin-1 Polyclonal Antibody (CAB9828)Western blot analysis of extracts of various cell lines, using LCN1 antibody (CAB9828) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-Lipocalin-1 Polyclonal Antibody (CAB9828)Immunohistochemistry of paraffin-embedded human prostate using LCN1 antibody (CAB9828) at dilution of 1:100 (40x lens).

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