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Anti-LY96 Antibody (CAB1866)

SKU:
CAB1866
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-LY96 Antibody
Antibody SKU:CAB1866
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human LY96 (NP_056179.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver, Mouse spleen, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human LY96 (NP_056179.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QKQY WVCN SSDA SISY TYCD KMQY PISI NVNP CIEL KGSK GLLH IFYI PRRD LKQL YFNL YITV NTMN LPKR KEVI CRGS DDDY SFCR ALKG ETVN TTIS FSFK GIKF SKGK YKCV VEAI SGSP EEML FCLE FVIL HQPN SN
Gene ID:23643
Uniprot:Q9Y6Y9
Cellular Location:Secreted, extracellular space
Calculated MW:14kDa/18kDa
Observed MW:25kDa
Synonyms:LY96, ESOP-1, MD-2, MD2, ly-96
Background:This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: extracellular space; plasma membrane; lipopolysaccharide receptor complex; endosome membrane

Molecular Function:protein binding; lipopolysaccharide receptor activity; coreceptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cell surface receptor linked signal transduction; detection of lipopolysaccharide; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; innate immune response; cellular defense response; inflammatory response; toll-like receptor 4 signaling pathway

NCBI Summary:This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
UniProt Code:Q9Y6Y9
NCBI GenInfo Identifier:296434574
NCBI Gene ID:23643
NCBI Accession:Q9Y6Y9.2
UniProt Secondary Accession:Q9Y6Y9,B3Y6A5, E5RJJ7,
UniProt Related Accession:Q9Y6Y9
Molecular Weight:160
NCBI Full Name:Lymphocyte antigen 96
NCBI Synonym Full Names:lymphocyte antigen 96
NCBI Official Symbol:LY96  
NCBI Official Synonym Symbols:MD2; MD-2; ly-96; ESOP-1  
NCBI Protein Information:lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2
UniProt Protein Name:Lymphocyte antigen 96
UniProt Synonym Protein Names:ESOP-1; Protein MD-2
Protein Family:Lymphocyte antigen
UniProt Gene Name:LY96  
UniProt Entry Name:LY96_HUMAN
Anti-LY96 Antibody (CAB1866)Western blot analysis of extracts of various cell lines, using LY96 antibody (CAB1866) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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