MED16 Antibody (PACO17237)
- SKU:
- PACO17237
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | MED16 Antibody (PACO17237) |
| Antibody SKU: | PACO17237 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human MED16 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17237(MED16 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 and hela cell, Primary antibody: PACO17237(MED16 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17237(MED16 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Synonyms: | mediator complex subunit 16 |
| UniProt Protein Function: | MED16: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 16 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Receptor, misc.Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: membrane; nucleoplasm; Srb-mediator complexMolecular Function: protein binding; receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription cofactor activityBiological Process: androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y2X0 |
| NCBI GenInfo Identifier: | 62511180 |
| NCBI Gene ID: | 10025 |
| NCBI Accession: | Q9Y2X0.2 |
| UniProt Secondary Accession: | Q9Y2X0,Q6PJT2, Q96AD4, Q96I35, Q9Y652 |
| UniProt Related Accession: | Q9Y2X0 |
| Molecular Weight: | 72,967 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 16 |
| NCBI Synonym Full Names: | mediator complex subunit 16 |
| NCBI Official Symbol: | MED16Â Â |
| NCBI Official Synonym Symbols: | DRIP92; THRAP5; TRAP95Â Â |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 16 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 16 |
| UniProt Synonym Protein Names: | Mediator complex subunit 16; Thyroid hormone receptor-associated protein 5; Thyroid hormone receptor-associated protein complex 95 kDa component; Trap95; Vitamin D3 receptor-interacting protein complex 92 kDa component; DRIP92 |
| Protein Family: | Putative mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED16Â Â |
| UniProt Entry Name: | MED16_HUMAN |
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