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Anti-MEPCE Antibody (CAB7121)

SKU:
CAB7121
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-MEPCE Antibody
Antibody SKU:CAB7121
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVGL DIDS RLIH SARQ NIRH YLSE ELRL PPQT LEGD PGAE GEEG TTTV RKRS CFPA SLTA SRGP IAAP QVPL DGAD TSVF PNNV VFVT GNYV LDRD DLVE AQTP EYDV VLCL SLTK WVHL NWGD EGLK RMFR RIYR HLRP GGIL VLEP QPWS SYGK RKTL TETI YKNY YRIQ LKPE QFSS YLTS PDVG FSSY ELVA TPHN TSKG FQRP VYLF HKAR SPSH
Gene ID:56257
Uniprot:Q7L2J0
Cellular Location:
Calculated MW:24kDa/74kDa
Observed MW:Refer to figures
Synonyms:MEPCE, BCDIN3
Background:
UniProt Protein Function:BCDIN3: a CDK9-associated enzyme that forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates CDK9 activity. An adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to its stabilization. Component of the 7SK snRNP complex that contains P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. Contains a Bin3 domain found in a number of protein methyltransferases that modify RNA-binding proteins.
UniProt Protein Details:

Protein type:Transcription regulation; Methyltransferase; RNA processing; EC 2.1.1.; EC 2.1.1.-

Chromosomal Location of Human Ortholog: 7q22.1

Molecular Function:RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: RNA methylation; snRNA metabolic process; snRNA modification

UniProt Code:Q7L2J0
NCBI GenInfo Identifier:74758999
NCBI Gene ID:56257
NCBI Accession:Q7L2J0.1
UniProt Secondary Accession:Q7L2J0,Q9NPD4, B3KP86, D6W5V7,
UniProt Related Accession:Q7L2J0
Molecular Weight:24,950 Da
NCBI Full Name:7SK snRNA methylphosphate capping enzyme
NCBI Synonym Full Names:methylphosphate capping enzyme
NCBI Official Symbol:MEPCE  
NCBI Official Synonym Symbols:BCDIN3  
NCBI Protein Information:7SK snRNA methylphosphate capping enzyme
UniProt Protein Name:7SK snRNA methylphosphate capping enzyme
UniProt Synonym Protein Names:Bicoid-interacting protein 3 homolog; Bin3 homolog
Protein Family:7SK snRNA methylphosphate capping enzyme
UniProt Gene Name:MEPCE  
UniProt Entry Name:MEPCE_HUMAN
Anti-MEPCE Antibody (CAB7121)Immunofluorescence analysis of A549 cells using MEPCE antibody (CAB7121).

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