Description
MUM1 Antibody (PACO10659)
The MUM1 Antibody (PACO10659) is a highly specific monoclonal antibody designed for research involving MUM1, also known as IRF4, a transcription factor involved in the regulation of immune responses. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in immunohistochemistry applications. MUM1/IRF4 is a key regulator of plasma cell differentiation and plays a critical role in the pathogenesis of various hematological malignancies, making it a valuable target for research in cancer biology and immunology. By specifically binding to MUM1/IRF4 protein, this antibody enables precise detection and analysis in various cell types, providing researchers with a valuable tool for studying the role of MUM1/IRF4 in disease development and progression.
Understanding the function and regulation of MUM1/IRF4 is essential for developing targeted therapies for cancers and autoimmune disorders where MUM1/IRF4 dysregulation is implicated. The MUM1 Antibody (PACO10659) offers researchers a reliable and specific tool for investigating the role of MUM1/IRF4 in disease pathology and developing novel therapeutic strategies.
| Antibody Name: | MUM1 Antibody (PACO10659) |
| Antibody SKU: | PACO10659 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human MUM1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | melanoma associated antigen (mutated) 1;MUM1;FLJ14868;FLJ22283;HSPC211;MGC131891;MGC163315;MUM-1 ; |
| UniProt Protein Function: | MUM1: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. Belongs to the MUM1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:nucleosome binding; protein binding Biological Process: DNA repair; establishment and/or maintenance of chromatin architecture |
| UniProt Code: | Q2TAK8 |
| NCBI GenInfo Identifier: | 259016340 |
| NCBI Gene ID: | 84939 |
| NCBI Accession: | Q2TAK8.3 |
| UniProt Related Accession: | Q2TAK8 |
| Molecular Weight: | 78.6kDa |
| NCBI Full Name: | PWWP domain-containing DNA repair factor 3A |
| NCBI Synonym Full Names: | PWWP domain containing 3A, DNA repair factor |
| NCBI Official Symbol: | PWWP3AÂ Â |
| NCBI Official Synonym Symbols: | MUM1; MUM-1; EXPAND1; HSPC211Â Â |
| NCBI Protein Information: | PWWP domain-containing DNA repair factor 3A |
| UniProt Protein Name: | PWWP domain-containing protein MUM1 |
| UniProt Synonym Protein Names: | Mutated melanoma-associated antigen 1; MUM-1; Protein expandere |
| Protein Family: | PWWP domain-containing protein |
| UniProt Gene Name: | MUM1Â Â |
