PAPPA Antibody (PACO32280)
- SKU:
- PACO32280
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | PAPPA Antibody (PACO32280) |
| Antibody SKU: | PACO32280 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pappalysin-1 protein (95-302AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO32280 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32280 at dilution of 1:100. |
| Background: | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
| Synonyms: | Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A), PAPPA |
| UniProt Protein Function: | PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.79; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 9q33.2 Cellular Component: membrane; extracellular region Molecular Function:metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis |
| NCBI Summary: | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] |
| UniProt Code: | Q13219 |
| NCBI GenInfo Identifier: | 223590248 |
| NCBI Gene ID: | 5069 |
| NCBI Accession: | Q13219.3 |
| UniProt Related Accession: | Q13219 |
| Molecular Weight: | Predicted MW: 25.9kDaAccurate MW: 33kDa |
| NCBI Full Name: | Pappalysin-1 |
| NCBI Synonym Full Names: | pappalysin 1 |
| NCBI Official Symbol: | PAPPAÂ Â |
| NCBI Official Synonym Symbols: | PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase  |
| NCBI Protein Information: | pappalysin-1 |
| UniProt Protein Name: | Pappalysin-1 |
| UniProt Synonym Protein Names: | Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A |
| Protein Family: | Pappalysin |
| UniProt Gene Name: | PAPPAÂ Â |
| UniProt Entry Name: | PAPP1_HUMAN |
| ELISA Kits |
| Human PAPPA (Pregnancy Associated Plasma Protein A) CLIA Kit (HUES00129) |
| Human PAPPA (Pregnancy Associated Plasma Protein A) ELISA Kit (HUES01420) |
| Human Pappalysin-1 (PAPPA) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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