Phospho-CAMK2A/CAMK2B/CAMK2D (T305) Antibody (PACO06155)

Antibody Name:	Phospho-CAMK2A/CAMK2B/CAMK2D (T305) Antibody (PACO06155)
Antibody SKU:	PACO06155
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human CaMKII α / β / delta around the phosphorylation site of T305.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot analysis of 453 293T cells using Phospho-CaMKII alpha / beta / delta (T305) Polyclonal Antibody.
	Western Blot analysis of 453 cells using Phospho-CaMKIIalpha / beta / delta (T305) Polyclonal Antibody.

Synonyms:

CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit α; CaM kinase II subunit α; CaMK-II subunit α; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit β; Ca

UniProt Protein Function:	CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane Molecular Function:calmodulin binding; glutamate receptor binding; kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: activation of NF-kappaB transcription factor; calcium ion transport; G1/S transition of mitotic cell cycle; MAPKKK cascade; peptidyl-serine phosphorylation; positive regulation of calcium ion transport; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; Wnt receptor signaling pathway, calcium modulating pathway
NCBI Summary:	The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
UniProt Code:	Q9UQM7
NCBI GenInfo Identifier:	296434552
NCBI Gene ID:	815
NCBI Accession:	Q9UQM7.2
UniProt Secondary Accession:	Q9UQM7,Q9UL21, Q9Y2H4, Q9Y352,
UniProt Related Accession:	Q9UQM7
Molecular Weight:	55,320 Da
NCBI Full Name:	Calcium/calmodulin-dependent protein kinase type II subunit alpha
NCBI Synonym Full Names:	calcium/calmodulin dependent protein kinase II alpha
NCBI Official Symbol:	CAMK2A
NCBI Official Synonym Symbols:	CAMKA
NCBI Protein Information:	calcium/calmodulin-dependent protein kinase type II subunit alpha
UniProt Protein Name:	Calcium/calmodulin-dependent protein kinase type II subunit alpha
Protein Family:	Calcium/calmodulin-dependent protein kinase
UniProt Gene Name:	CAMK2A
UniProt Entry Name:	KCC2A_HUMAN

Antibodies

CAMK2A/CAMK2B/CAMK2D Antibody (PACO05422)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)