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Anti-PLA2G4C Antibody (CAB7753)

SKU:
CAB7753
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-PLA2G4C Antibody CAB7753
  • Metabolism Antibodies 2 Anti-PLA2G4C Antibody CAB7753
  • Metabolism Antibodies 2 Anti-PLA2G4C Antibody CAB7753
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PLA2G4C Antibody
Antibody SKU:CAB7753
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human PLA2G4C (NP_003697.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human PLA2G4C (NP_003697.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSS EVSI IPGL QKEE KAAV ERRR LHVL KALK KLRI EADE APVV AVLG SGGG LRAH IACL GVLS EMKE QGLL DAVT YLAG VSGS TWAI SSLY TNDG DMEA LEAD LKHR FTRQ EWDL AKSL QKTI QAAR SENY SLTD FWAY MVIS KQTR ELPE SHLS NMKK PVEE GTLP YPIF AAID NDLQ PSWQ EARA P
Gene ID:8605
Uniprot:Q9UP65
Cellular Location:Lipid-anchor, Membrane
Calculated MW:59kDa/60kDa/62kDa
Observed MW:80kDa
Synonyms:PLA2G4C, CPLA2-gamma
Background:This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PLA2G4C: a calcium-independent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. Highly expressed in heart and skeletal muscle.
UniProt Protein Details:

Protein type:Phospholipase; Lipid Metabolism - arachidonic acid; EC 3.1.1.4

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; nuclear envelope; cell cortex; cytosol

Molecular Function:calcium-independent phospholipase A2 activity; phospholipid binding

Biological Process: glycerophospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; arachidonic acid metabolic process; parturition; inflammatory response

NCBI Summary:This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
UniProt Code:Q9UP65
NCBI GenInfo Identifier:226693357
NCBI Gene ID:8605
NCBI Accession:NP_001152794.1
UniProt Secondary Accession:Q9UP65,O75457, Q6IBI8, Q9UG68, B2RB71, B4DI40,
UniProt Related Accession:Q9UP65
Molecular Weight:62,451 Da
NCBI Full Name:cytosolic phospholipase A2 gamma isoform 2
NCBI Synonym Full Names:phospholipase A2, group IVC (cytosolic, calcium-independent)
NCBI Official Symbol:PLA2G4C  
NCBI Official Synonym Symbols:CPLA2-gamma  
NCBI Protein Information:cytosolic phospholipase A2 gamma; phospholipase A2 group IVC
UniProt Protein Name:Cytosolic phospholipase A2 gamma
UniProt Synonym Protein Names:Phospholipase A2 group IVC
Protein Family:Cytosolic phospholipase
UniProt Gene Name:PLA2G4C  
UniProt Entry Name:PA24C_HUMAN
Anti-PLA2G4C Antibody (CAB7753)Western blot analysis of extracts of THP-1 cells, using PLA2G4C antibody (CAB7753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PLA2G4C Antibody (CAB7753)Immunohistochemistry of paraffin-embedded human tonsil using PLA2G4C antibody (CAB7753) at dilution of 1:100 (40x lens).
Anti-PLA2G4C Antibody (CAB7753)Immunofluorescence analysis of U2OS cells using PLA2G4C antibody (CAB7753) at dilution of 1:100. Blue: DAPI for nuclear staining.

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