null

Anti-PROKR2 Antibody (CAB2960)

SKU:
CAB2960
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PROKR2 Antibody
Antibody SKU:CAB2960
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human PROKR2
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, SKOV3, 293T, Mouse thymus
Immunogen:A synthetic peptide of human PROKR2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:128674
Uniprot:Q8NFJ6
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:43kDa
Observed MW:50kDa
Synonyms:PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3
Background:Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.
UniProt Protein Function:PROKR2: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function:neuropeptide Y receptor activity

Biological Process: circadian rhythm; neuropeptide signaling pathway

Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia

NCBI Summary:Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NFJ6
NCBI GenInfo Identifier:33112425
NCBI Gene ID:128674
NCBI Accession:Q8NFJ6.1
UniProt Secondary Accession:Q8NFJ6,Q2M3C0, Q5TDY1, Q9NTT0, A5JUU1,
UniProt Related Accession:Q8NFJ6
Molecular Weight:384
NCBI Full Name:Prokineticin receptor 2
NCBI Synonym Full Names:prokineticin receptor 2
NCBI Official Symbol:PROKR2  
NCBI Official Synonym Symbols:HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3  
NCBI Protein Information:prokineticin receptor 2; PK-R2; G protein-coupled receptor 73-like 1
UniProt Protein Name:Prokineticin receptor 2
UniProt Synonym Protein Names:G-protein coupled receptor 73-like 1; GPR73b; GPRg2
Protein Family:Prokineticin receptor
UniProt Gene Name:PROKR2  
UniProt Entry Name:PKR2_HUMAN
Anti-PROKR2 Antibody (CAB2960)Western blot analysis of extracts of various cell lines, using PROKR2 antibody (CAB2960) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Related Products