RAMP2 Rabbit Polyclonal Antibody (CAB3075)
- SKU:
- CAB3075
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | RAMP2 Rabbit Polyclonal Antibody |
SKU: | CAB3075 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RAMP2 (NP_005845.2). |
Sequence: | MASL RVER AGGP RLPR TRVG RPAA LRLL LLLG AVLN PHEA LAQP LPTT GTPG SEGG TVKN YETA VQFC WNHY KDQM DPIE KDWC DWAM ISRP YSTL RDCL EHFA ELFD LGFP NPLA ERII FETH QIHF ANCS LVQP TFSD PPED V |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | RAMP2 |
Positive Sample: | A-549,BxPC-3,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 20kDa |
Observed MW: | 15kDa |
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Purification Method: | Affinity purification |
Gene ID: | 10266 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |