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Anti-RBMS1 Antibody (CAB3079)

SKU:
CAB3079
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

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Antibody Name:Anti-RBMS1 Antibody
Antibody SKU:CAB3079
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RBMS1 (NP_002888.1).
Application:WB IHC IF
Recommended Dilution:WB 1:200 - 1:1000 IHC 1:20 - 1:100 IF 1:20 - 1:100
Reactivity:Human
Positive Samples:NCI-H460, HeLa, MCF7, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RBMS1 (NP_002888.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGKV WKQQ MYPQ YATY YYPQ YLQA KQSL VPAH PMAP PSPS TTSS NNNS SSSS NSGW DQLS KTNL YIRG LPPH TTDQ DLVK LCQP YGKI VSTK AILD KTTN KCKG YGFV DFDS PAAA QKAV SALK ASGV QAQM AKQQ EQDP TNLY ISNL PLSM DEQE LENM LKPF GQVI STRI LRDS SGTS RGVG FARM ESTE KCEA VIGH FNGK FIKT PPGV SAPT EPLL CKFA DGGQ KKRQ NPNK YIPN GRPW HREG EAGM TLTY DPTT
Gene ID:5937
Uniprot:P29558
Cellular Location:Nucleus
Calculated MW:4kDa/44kDa
Observed MW:50kDa
Synonyms:RBMS1, C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1
Background:This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12.
UniProt Protein Function:RBMS1: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA replication; RNA-binding

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: nucleus

Molecular Function:protein binding; RNA binding; double-stranded DNA binding; nucleotide binding; single-stranded DNA binding

Biological Process: RNA processing; DNA replication

NCBI Summary:This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
UniProt Code:P29558
NCBI GenInfo Identifier:55977783
NCBI Gene ID:5937
NCBI Accession:P29558.3
UniProt Related Accession:P29558
Molecular Weight:
NCBI Full Name:RNA-binding motif, single-stranded-interacting protein 1
NCBI Synonym Full Names:RNA binding motif single stranded interacting protein 1
NCBI Official Symbol:RBMS1  
NCBI Official Synonym Symbols:YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12  
NCBI Protein Information:RNA-binding motif, single-stranded-interacting protein 1
UniProt Protein Name:RNA-binding motif, single-stranded-interacting protein 1
UniProt Synonym Protein Names:Single-stranded DNA-binding protein MSSP-1; Suppressor of CDC2 with RNA-binding motif 2
Protein Family:RNA-binding motif, single-stranded-interacting protein
UniProt Gene Name:RBMS1  
UniProt Entry Name:RBMS1_HUMAN
Anti-RBMS1 Antibody (CAB3079)Western blot analysis of extracts of various cell lines, using RBMS1 antibody (CAB3079) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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