|UniProt Protein Function:||Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Ref.13|
|UniProt Protein Details:|
Subunit structure: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Ref.8 Ref.9 Ref.10 Ref.11 Ref.13 Ref.14
Subcellular location: Cytoplasm.
Tissue specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
Sequence similarities: Belongs to the S-100 family.Contains 2 EF-hand domains.
|NCBI Summary:||The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]|
|NCBI GenInfo Identifier:||134136|
|NCBI Gene ID:||6271|
|UniProt Secondary Accession:||P23297,Q5T7Y3, B2R5D9,|
|UniProt Related Accession:||P23297|
|NCBI Full Name:||Protein S100-A1|
|NCBI Synonym Full Names:||S100 calcium binding protein A1|
|NCBI Official Symbol:||S100A1 |
|NCBI Official Synonym Symbols:||S100; S100A; S100-alpha |
|NCBI Protein Information:||protein S100-A1; S100 alpha; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1; S100 protein, alpha polypeptide|
|UniProt Protein Name:||Protein S100-A1|
|UniProt Synonym Protein Names:||S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1|
|UniProt Gene Name:||S100A1 |
|UniProt Entry Name:||S10A1_HUMAN|