Anti-SERPINA7 Antibody (CAB6313)

Antibody Name:	Anti-SERPINA7 Antibody
Antibody SKU:	CAB6313
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 146-415 of human SERPINA7 (NP_000345.2).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	Muose heart, Mouse pancreas, Rat liver, Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 146-415 of human SERPINA7 (NP_000345.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	FLND VKTL YETE VFST DFSN ISAA KQEI NSHV EMQT KGKV VGLI QDLK PNTI MVLV NYIH FKAQ WANP FDPS KTED SSSF LIDK TTTV QVPM MHQM EQYY HLVD MELN CTVL QMDY SKNA LALF VLPK EGQM ESVE AAMS SKTL KKWN RLLQ KGWV DLFV PKFS ISAT YDLG ATLL KMGI QHAY SENA DFSG LTED NGLK LSNA AHKA VLHI GEKG TEAA AVPE VELS DQPE NTFL HPII QIDR SFML LILE RSTR SILF LGKV VNPT EA
Gene ID:	6906
Uniprot:	P05543
Cellular Location:	Secreted
Calculated MW:	46kDa
Observed MW:	46kDa

Synonyms:

SERPINA7, TBG, TBGQTL

Background:

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

UniProt Protein Function:	SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: Xq22.2 Molecular Function:serine-type endopeptidase inhibitor activity
NCBI Summary:	There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
UniProt Code:	P05543
NCBI GenInfo Identifier:	1351236
NCBI Gene ID:	6906
NCBI Accession:	P05543.2
UniProt Secondary Accession:	P05543,D3DUX1,
UniProt Related Accession:	P05543
Molecular Weight:	46,325 Da
NCBI Full Name:	Thyroxine-binding globulin
NCBI Synonym Full Names:	serpin family A member 7
NCBI Official Symbol:	SERPINA7
NCBI Official Synonym Symbols:	TBG
NCBI Protein Information:	thyroxine-binding globulin
UniProt Protein Name:	Thyroxine-binding globulin
UniProt Synonym Protein Names:	Serpin A7; T4-binding globulin
Protein Family:	Thyroxine-binding globulin
UniProt Gene Name:	SERPINA7
UniProt Entry Name:	THBG_HUMAN

	Western blot analysis of extracts of various cell lines, using SERPINA7 antibody (CAB6313) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
	Immunohistochemistry of paraffin-embedded human liver using SERPINA7 antibody (CAB6313) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse stomach using SERPINA7 antibody (CAB6313) at dilution of 1:100 (40x lens).

ELISA Kits

Human TBG / SERPINA7 ELISA Kit

Human TBG (Thyroxine Binding Globulin) CLIA Kit (HUES00844)

Human Thyroxine-binding globulin (SERPINA7) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)