Anti-SLCO1B1 Antibody (CAB17082)

SKU:
CAB17082
€99 - €249

Description

Technical Manual

Anti-SLCO1B1 Antibody

Product Name:Anti-SLCO1B1 Antibody
Product SKU:CAB17082
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3).
Sequence:

TTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC

Gene ID:10599
Swiss Prot:Q9Y6L6
Synonyms:SLCO1B1; HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6
Calculated MW:76kDa
Observed MW:Refer to figures
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:
Cellular Location:

Uniprot Information

UniProt Protein Function:SLCO1B1: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B1 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 12p

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity

Biological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transport

Disease: Hyperbilirubinemia, Rotor Type

NCBI Summary:This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
UniProt Code:Q9Y6L6
NCBI GenInfo Identifier:12643959
NCBI Gene ID:10599
NCBI Accession:Q9Y6L6.2
UniProt Secondary Accession:Q9Y6L6,Q29R64, Q9NQ37, Q9UBF3, Q9UH89, B2R7G2,
UniProt Related Accession:Q9Y6L6
Molecular Weight:76,449 Da
NCBI Full Name:Solute carrier organic anion transporter family member 1B1
NCBI Synonym Full Names:solute carrier organic anion transporter family member 1B1
NCBI Official Symbol:SLCO1B1
NCBI Official Synonym Symbols:LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6
NCBI Protein Information:solute carrier organic anion transporter family member 1B1
UniProt Protein Name:Solute carrier organic anion transporter family member 1B1
UniProt Synonym Protein Names:Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6
Protein Family:Solute carrier organic anion transporter family
UniProt Gene Name:SLCO1B1
UniProt Entry Name:SO1B1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
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