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Anti-OX40 Antibody (CAB3646)

SKU:
CAB3646
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-OX40 Antibody
Antibody SKU:CAB3646
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TATQ DTVC RCRA GTQP LDSY KPGV DCAP CPPG HFSP GDNQ ACKP WTNC TLAG KHTL QPAS NSSD AICE DRDP PATQ PQET QGPP ARPI TVQP TEAW PRTS Q
Gene ID:7293
Uniprot:P43489
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:29kDa
Observed MW:48kDa
Synonyms:TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L
Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
UniProt Protein Function:TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
UniProt Protein Details:

Protein type:Apoptosis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function:tumor necrosis factor receptor activity

Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity

Disease: Immunodeficiency 16

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
UniProt Code:P43489
NCBI GenInfo Identifier:1171933
NCBI Gene ID:7293
NCBI Accession:P43489.1
UniProt Related Accession:P43489
Molecular Weight:
NCBI Full Name:Tumor necrosis factor receptor superfamily member 4
NCBI Synonym Full Names:TNF receptor superfamily member 4
NCBI Official Symbol:TNFRSF4  
NCBI Official Synonym Symbols:OX40; ACT35; CD134; IMD16; TXGP1L  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 4
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 4
UniProt Synonym Protein Names:ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134
UniProt Gene Name:TNFRSF4  
UniProt Entry Name:TNR4_HUMAN
Anti-OX40 Antibody (CAB3646)Western blot analysis of extracts of rat liver, using OX40 antibody (CAB3646) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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