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Leptospirosis Antibodies, Proteins & ELISA Kits

Leptospirosis Antibodies, Proteins & ELISA Kits | Assay Genie
Infectious Disease · Leptospira species

Leptospirosis antibodies, proteins & ELISA kits

Leptospirosis is a zoonotic infection caused by spirochaetes of the genus Leptospira, ranging from mild febrile illness to severe Weil's disease with jaundice and renal failure.

LeptospiraLipL32Zoonotic
Leptospira
Spirochaete
LipL32
Major antigen
Water / rodents
Exposure
Weil's disease
Severe form
Overview

What is Leptospirosis?

Leptospirosis is a zoonotic infection caused by spirochaetes of the genus Leptospira, ranging from mild febrile illness to severe Weil's disease with jaundice and renal failure.

Humans are infected through water or soil contaminated with animal urine. Anti-Leptospira IgM/IgG serology and the conserved LipL32 antigen support diagnosis and serosurveillance.

Transmission & symptoms

Leptospirosis is a zoonosis caused by spirochaetes of the genus Leptospira. People are infected through water or soil contaminated with the urine of infected animals; disease ranges from a mild flu-like illness to severe Weil disease with jaundice, renal failure and haemorrhage.

Diagnosis & serology

The reference serological test is the microscopic agglutination test, with ELISA measuring anti-Leptospira IgM/IgG. The conserved outer-membrane lipoprotein LipL32 is a leading recombinant antigen for serodiagnosis.

Research applications

Research tools support Leptospira serodiagnosis, innate immune recognition (TLR2, TLR4), complement evasion and vaccine-antigen studies.

FAQs

Leptospirosis — frequently asked questions

How is leptospirosis diagnosed serologically?
By the microscopic agglutination test (reference method) and ELISA for anti-Leptospira IgM/IgG; PCR is used in early acute disease.
What is LipL32?
LipL32 is a conserved, highly expressed outer-membrane lipoprotein of pathogenic Leptospira and a leading recombinant antigen for serodiagnostic assays.
How do people catch leptospirosis?
Through contact with water or soil contaminated by the urine of infected animals, often via cuts or mucous membranes during recreational or occupational exposure.

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