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An overview of Wnt Signalling The Wnt signalling pathway is an evolutionarily conserved pathway that plays critical roles in the regulation of determining cell fate, polarity, migration, neural patterning and organogenesis during embryonic development (Komiya and Habas, 2008). Components of this signalling pathway were discovered in the 1980’s by a number of researchers working in both mouse and Drosophila models. The name ‘Wnt’ originated from a combin …