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ABCB11 Rabbit Polyclonal Antibody (CAB8467)

SKU:
CAB8467
Product Type:
Antibody
Applications:
WB
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-ABCB11 Antibody CAB8467
  • Signal Transduction Antibodies 3 Anti-ABCB11 Antibody CAB8467
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ABCB11 Rabbit Polyclonal Antibody
SKU:CAB8467
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human ABCB11 (NP_003733.2).
Sequence:RFFQ LLDR QPPI SVYN TAGE KWDN FQGK IDFV DCKF TYPS RPDS QVLN GLSV SISP GQTL AFVG SSGC GKST SIQL LERF YDPD QGKV MIDG HDSK KVNV Q
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; ABCB11
Positive Sample:Mouse liver
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:146kDa
Observed MW:160kDa

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Purification Method:Affinity purification
Gene ID:8647
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of Mouse liver, using ABCB11 antibody (CAB8467) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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