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Anti-UGT2B4 Antibody (CAB4180)

SKU:
CAB4180
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-UGT2B4 Antibody
Antibody SKU:CAB4180
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human UGT2B4 (NP_066962.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:22Rv1, B cells, HT-1080, Mouse liver, Mouse brain, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human UGT2B4 (NP_066962.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LHCK PAKP LPKE MEEF VQSS GENG VVVF SLGS MVSN TSEE RANV IASA LAKI PQKV LWRF DGNK PDTL GLNT RLYK WIPQ NDLL GHPK TRAF ITHG GANG IYEA IYHG IPMV GVPL FADQ PDNI AHMK AKGA AVSL DFHT MSST DLLN ALKT VIND PLYK ENAM KLSR IHHD QPVK PLDR AVFW IEFV MRHK GAKH LRVA A
Gene ID:7363
Uniprot:P06133
Cellular Location:Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein
Calculated MW:42kDa/44kDa/60kDa
Observed MW:50kDa
Synonyms:UGT2B4, HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11
Background:
UniProt Protein Function:UGT2B4: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid. Belongs to the UDP-glycosyltransferase family.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - pentose and glucuronate interconversions; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function:retinoic acid binding; glucuronosyltransferase activity

Biological Process: flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process; estrogen catabolic process; cellular response to hormone stimulus

UniProt Code:P06133
NCBI GenInfo Identifier:6175083
NCBI Gene ID:7363
NCBI Accession:P06133.2
UniProt Secondary Accession:P06133,O60731, O60867, O75614, P36538, Q1HBF9, Q6QQX7 A6NCP7, B4DT75, G5E9X8,
UniProt Related Accession:P06133
Molecular Weight:Observed MW: 50kDaCalculated MW: 42kDa/44kDa/60kDa
NCBI Full Name:UDP-glucuronosyltransferase 2B4
NCBI Synonym Full Names:UDP glucuronosyltransferase 2 family, polypeptide B4
NCBI Official Symbol:UGT2B4  
NCBI Official Synonym Symbols:HLUG25; UDPGTH1; UGT2B11; UDPGT2B4; UDPGTh-1  
NCBI Protein Information:UDP-glucuronosyltransferase 2B4; UDPGT 2B4; hyodeoxycholic acid; hyodeoxycholic acid-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-4
UniProt Protein Name:UDP-glucuronosyltransferase 2B4
UniProt Synonym Protein Names:HLUG25; Hyodeoxycholic acid-specific UDPGT; UDPGTh-1
Protein Family:UDP-glucuronosyltransferase
UniProt Gene Name:UGT2B4  
UniProt Entry Name:UD2B4_HUMAN
Anti-UGT2B4 Antibody (CAB4180)Western blot analysis of extracts of various cell lines, using UGT2B4 antibody (CAB4180) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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