Anti-BCMA bispecific antibody (DM4) (HDAB0001)

SKU:: HDAB0001
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€681

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Description

Description

Description	BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Product name	Anti-BCMA bispecific antibody (DM4)
Synonyms	TNFRSF17
Type	Primary
Quantity	100 µL
Shipping	Blue Ice
Antigen	BCMA
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Clone	DM4
Isotype	Rabbit scfv
Application	Flow Cyt, MM Tumor cell killing
Immunogen substitute	Recombinant human BCMA (Met1-Ala54) (HDPT0001) produced by using human HEK293 cells
Purification	Purified from cell culture supernatant by affinity chromatography
Format	Liquid
Storage	Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage	Research use only
Buffer	50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative	0.1% Procline 300
Reconstitution	Reconstitute with deionized water
Application Advice	Flow Cyt 1/100; MMTumor cell killing
Gene ID	608
Swiss-Prot	608
Molecular Weight	20kDa
Assay Genie Related SKUs	HDPT0001

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