Anti-BCMA bispecific antibody (DM4) (HDAB0001)

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Description BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Product name Anti-BCMA bispecific antibody (DM4)
Synonyms TNFRSF17
Type Primary
Quantity 100 µL
Shipping Blue Ice
Antigen BCMA
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone DM4
Isotype Rabbit scfv
Application Flow Cyt, MM Tumor cell killing
Immunogen substitute Recombinant human BCMA (Met1-Ala54) (HDPT0001) produced by using human HEK293 cells
Purification Purified from cell culture supernatant by affinity chromatography
Format Liquid
Storage Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Buffer 50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative 0.1% Procline 300
Reconstitution Reconstitute with deionized water
Application Advice Flow Cyt  1/100; MMTumor cell killing
Gene ID 608
Swiss-Prot 608
Molecular Weight 20kDa
Assay Genie Related SKUs HDPT0001