Anti-CD33 antibody (DM77) Rabbit mAb (HDAB0064)
- SKU:
- HDAB0064
Frequently bought together:
Description
| Description | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K. |
| Product name | Anti-CD33 antibody (DM77) Rabbit mAb |
| Synonyms | CD33,SIGLEC3,gp67 |
| Type | Primary |
| Quantity | 100 µL |
| Shipping | Blue Ice |
| Antigen | CD33 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | DM77 |
| Isotype | Rabbit IgG |
| Application | ELISA,Flow Cyt |
| Immunogen substitute | Recombinant human CD33 (Asp18-His269) (HDPT0037) produced by using human HEK293 cells |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Format | Liquid |
| Storage | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
| Usage | Research use only |
| Buffer | 50% Glycerol; PBS, pH 7.4; 0.1% BSA |
| Preservative | 0.1% Procline 300 |
| Reconstitution | Reconstitute with deionized water |
| Application Advice | ELISA 1/5000-10000;Flow Cyt 1/100 |
| Gene ID | 945 |
| Swiss-Prot | P20138 |
| Molecular Weight | 39.8kDa |
| Assay Genie Related SKUs | HDPT0037 |
Related Products
Anti-CD138 antibody (DM45) Rabbit mAb (HDAB0035)
€630
DescriptionSyndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans...
HDAB0035
Anti-CD28 antibody (DM64) Rabbit mAb (HDAB0054)
€630
DescriptionThe protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants...
HDAB0054
Anti-2B4 antibody (DM69) Rabbit mAb (HDAB0056)
€630
DescriptionThis gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The...
HDAB0056
Anti-TIM3 antibody (DM81) Rabbit mAb (HDAB0068)
€630
DescriptionThe protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on...
HDAB0068
Anti-NKp30 antibody (DM88) Rabbit mAb (HDAB0075)
€630
DescriptionThe protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell...
HDAB0075
