Anti-CD33 antibody (DM77) Rabbit mAb (HDAB0064)

SKU:
HDAB0064
€630

Description

DescriptionSialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Product nameAnti-CD33 antibody (DM77) Rabbit mAb
SynonymsCD33,SIGLEC3,gp67
TypePrimary
Quantity100 µL
ShippingBlue Ice
AntigenCD33
ReactivityHuman
HostRabbit
ClonalityMonoclonal
CloneDM77
IsotypeRabbit IgG
ApplicationELISA,Flow Cyt
Immunogen substituteRecombinant human CD33 (Asp18-His269) (HDPT0037) produced by using human HEK293 cells
PurificationPurified from cell culture supernatant by affinity chromatography
FormatLiquid
StorageStore at -20°C for 12 months (Avoid repeated freezing and thawing)
UsageResearch use only
Buffer50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative0.1% Procline 300
ReconstitutionReconstitute with deionized water
Application AdviceELISA 1/5000-10000;Flow Cyt  1/100
Gene ID945
Swiss-ProtP20138
Molecular Weight39.8kDa
Assay Genie Related SKUsHDPT0037
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