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Anti-CS1 antibody (DM10) Rabbit mAb (HDAB0007)

SKU:
HDAB0007
€749
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Description

DescriptionSelf-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Product nameAnti-CS1 antibody (DM10) Rabbit mAb
SynonymsSLAM7 (19A, CD319, CRACC, CS1)
TypePrimary
Quantity100 µL
ShippingBlue Ice
AntigenCS1
ReactivityHuman
HostRabbit
ClonalityMonoclonal
CloneDM10
IsotypeRabbit IgG
ApplicationELISA, Flow Cyt, IP, IF
Immunogen substituteRecombinant human CS1 (Ser23-Met226) (HDPT0002) produced by using human HEK293 cells
PurificationPurified from cell culture supernatant by affinity chromatography
FormatLiquid
StorageStore at -20°C for 12 months (Avoid repeated freezing and thawing)
UsageResearch use only
Buffer50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative0.1% Procline 300
ReconstitutionReconstitute with deionized water
Application AdviceFlow Cyt  1/100
Gene ID57823
Swiss-ProtQ9NQ25
Molecular Weight37kDa
Assay Genie Related SKUsHDPT0002