Description
Description | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Product name | Anti-GITR antibody (DM79) Rabbit mAb |
Synonyms | AITR, GITR, TNFRSF18, CD357 |
Type | Primary |
Quantity | 100 µL |
Shipping | Blue Ice |
Antigen | GITR |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Clone | DM79 |
Isotype | Rabbit IgG |
Application | ELISA,Flow Cyt |
Immunogen substitute | Recombinant human GITR (Gln266-Pro162) (HDPT0018) produced by using human HEK293 cells |
Purification | Purified from cell culture supernatant by affinity chromatography |
Format | Liquid |
Storage | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
Usage | Research use only |
Buffer | 50% Glycerol; PBS, pH 7.4; 0.1% BSA |
Preservative | 0.1% Procline 300 |
Reconstitution | Reconstitute with deionized water |
Application Advice | ELISA 1/5000-10000;Flow Cyt 1/100 |
Gene ID | 8784 |
Swiss-Prot | Q9Y5U5 |
Molecular Weight | 26.0kDa |
Assay Genie Related SKUs | HDPT0018 |