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Anti-Phospho-IKBKB-Y199 Antibody (CABP0369)

SKU:
CABP0369
Product Type:
Antibody
Applications:
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
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Description

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Antibody Name:Anti-Phospho-IKBKB-Y199 Antibody
Antibody SKU:CABP0369
Antibody Size:100 uL
Application:IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding Y199 of human IKKBeta
Application:IF
Recommended Dilution:IF 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A phospho specific peptide corresponding to residues surrounding Y199 of human IKKBeta
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3551
Uniprot:O14920
Cellular Location:Cytoplasm, Membrane raft, Nucleus
Calculated MW:29kDa/79kDa/85kDa/86kDa
Observed MW:
Phospho-IKKB-Y199 pAb (CABP0369)Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-IKKb-Y199 antibody (CABP0369).
Synonyms:IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, IKK beta
Background:The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
UniProt Protein Function:IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft

Molecular Function:protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis

Disease: Immunodeficiency 15

NCBI Summary:The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:O14920
NCBI GenInfo Identifier:14285497
NCBI Gene ID:3551
NCBI Accession:O14920.1
UniProt Secondary Accession:O14920,O75327, B4DZ30, B4E0U4,
UniProt Related Accession:O14920
Molecular Weight:86,564 Da
NCBI Full Name:Inhibitor of nuclear factor kappa-B kinase subunit beta
NCBI Synonym Full Names:inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Official Symbol:IKBKB  
NCBI Official Synonym Symbols:IKK2; IKKB; IMD15; NFKBIKB; IKK-beta  
NCBI Protein Information:inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
UniProt Protein Name:Inhibitor of nuclear factor kappa-B kinase subunit beta
UniProt Synonym Protein Names:I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta
UniProt Gene Name:IKBKB  
UniProt Entry Name:IKKB_HUMAN

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