Anti-PFDN6 Antibody (CAB10580)
- SKU:
- CAB10580
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PFDN6 Antibody |
| Antibody SKU: | CAB10580 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-129 of human PFDN6 (NP_055075.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-129 of human PFDN6 (NP_055075.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEL IQKK LQGE VEKY QQLQ KDLS KSMS GRQK LEAQ LTEN NIVK EELA LLDG SNVV FKLL GPVL VKQE LGEA RATV GKRL DYIT AEIK RYES QLRD LERQ SEQQ RETL AQLQ QEFQ RAQA AKAG APGK A |
| Gene ID: | 10471 |
| Uniprot: | O15212 |
| Cellular Location: | |
| Calculated MW: | 14kDa |
| Observed MW: | 14kDa |
| Synonyms: | PFDN6, H2-KE2, HKE2, KE-2, PFD6 |
| Background: |
| UniProt Protein Function: | PFDN6: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Belongs to the prefoldin subunit beta family. |
| UniProt Protein Details: | Protein type:Chaperone; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p21.32 Cellular Component: cytoplasm; prefoldin complex Molecular Function:chaperone binding Biological Process: chaperone-mediated protein complex assembly; protein folding |
| NCBI Summary: | PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | O15212 |
| NCBI GenInfo Identifier: | 6016432 |
| NCBI Gene ID: | 10471 |
| NCBI Accession: | O15212.1 |
| UniProt Related Accession: | O15212 |
| Molecular Weight: | Calculated: 14kDaObserved: 14kDa |
| NCBI Full Name: | Prefoldin subunit 6 |
| NCBI Synonym Full Names: | prefoldin subunit 6 |
| NCBI Official Symbol: | PFDN6Â Â |
| NCBI Official Synonym Symbols: | HKE2; KE-2; PFD6; H2-KE2Â Â |
| NCBI Protein Information: | prefoldin subunit 6 |
| UniProt Protein Name: | Prefoldin subunit 6 |
| UniProt Synonym Protein Names: | Protein Ke2 |
| Protein Family: | Prefoldin |
| UniProt Gene Name: | PFDN6Â Â |
 | Western blot analysis of extracts of mouse liver, using PFDN6 antibody (CAB10580) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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