null

Anti-RGS9 Antibody (CAB9326)

SKU:
CAB9326
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-RGS9 Antibody
Antibody SKU:CAB9326
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-350 of human RGS9 (NP_003826.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-350 of human RGS9 (NP_003826.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYYQ QALM RSTV KSSV SLGG IVKY SEQF SSND AIMS GCLP SNPW ITDD TQFW DLNA KLVE IPTK MRVE RWAF NFSE LIRD PKGR QSFQ YFLK KEFS GENL GFWE ACED LKYG DQSK VKEK A
Gene ID:8787
Uniprot:O75916
Cellular Location:Membrane, Peripheral membrane protein
Calculated MW:49kDa/54kDa/56kDa/76kDa
Observed MW:77kDa
Synonyms:RGS9, PERRS, RGS9L
Background:This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:RGS9: belongs to the 'regulator of G protein signaling' family. Inhibits signal transduction by increasing the GTPAse activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction. Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: cytoplasm; plasma membrane; heterotrimeric G-protein complex; nucleus

Molecular Function:signal transducer activity; protein complex binding; GTPase activator activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; nervous system development; regulation of rhodopsin mediated signaling; visual perception; response to estrogen stimulus; dopamine receptor signaling pathway; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

Disease: Prolonged Electroretinal Response Suppression

NCBI Summary:This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:O75916
NCBI GenInfo Identifier:8475983
NCBI Gene ID:8787
NCBI Accession:O75916.1
UniProt Related Accession:O75916
Molecular Weight:49kDa; 54kDa; 56kDa; 76kDa
NCBI Full Name:Regulator of G-protein signaling 9
NCBI Synonym Full Names:regulator of G protein signaling 9
NCBI Official Symbol:RGS9  
NCBI Official Synonym Symbols:PERRS; RGS9L  
NCBI Protein Information:regulator of G-protein signaling 9
UniProt Protein Name:Regulator of G-protein signaling 9
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS9  
UniProt Entry Name:RGS9_HUMAN

Related Products