Anti-Syntaxin-5 Antibody (CAB8455)

Antibody Name:	Anti-Syntaxin-5 Antibody
Antibody SKU:	CAB8455
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 55-355 of human STX5 (NP_003155.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Rat
Positive Samples:	Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 55-355 of human STX5 (NP_003155.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSCR DRTQ EFLS ACKS LQTR QNGI QTNK PALR AVRQ RSEF TLMA KRIG KDLS NTFA KLEK LTIL AKRK SLFD DKAV EIEE LTYI IKQD INSL NKQI AQLQ DFVR AKGS QSGR HLQT HSNT IVVS LQSK LASM SNDF KSVL EVRT ENLK QQRS RREQ FSRA PVSA LPLA PNHL GGGA VVLG AESH ASKD VAID MMDS RTSQ QLQL IDEQ DSYI QSRA DTMQ NIES TIVE LGSI FQQL AHMV KEQE ETIQ RIDE NVLG AQLD VEAA HSEI LKYF QSVT SNRW LMVK IFLI LIVF FIIF VVFL A
Gene ID:	6811
Uniprot:	Q13190
Cellular Location:	Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass type IV membrane protein
Calculated MW:	29kDa/34kDa/35kDa/39kDa
Observed MW:	45kDa

Synonyms:

STX5, SED5, STX5A

Background:

This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt Protein Function:	STX5: Mediates endoplasmic reticulum to Golgi transport. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; nucleoplasm; SNARE complex; vesicle Molecular Function:protein binding; protein N-terminus binding; SNAP receptor activity; SNARE binding Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process; retrograde transport, endosome to Golgi; vesicle docking; vesicle fusion
NCBI Summary:	This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:	Q13190
NCBI GenInfo Identifier:	114152881
NCBI Gene ID:	6811
NCBI Accession:	Q13190.2
UniProt Secondary Accession:	Q13190,Q5U0D4, Q7Z3T6, Q9BUG1, B2R8T2, F8W8Q9,
UniProt Related Accession:	Q13190
Molecular Weight:	35,474 Da
NCBI Full Name:	Syntaxin-5
NCBI Synonym Full Names:	syntaxin 5
NCBI Official Symbol:	STX5
NCBI Official Synonym Symbols:	SED5; STX5A
NCBI Protein Information:	syntaxin-5
UniProt Protein Name:	Syntaxin-5
Protein Family:	Syntaxin
UniProt Gene Name:	STX5
UniProt Entry Name:	STX5_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)