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Anti-TRIM13 Antibody (CAB6225)

SKU:
CAB6225
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
€139 - €419
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Description

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Antibody Name:Anti-TRIM13 Antibody
Antibody SKU:CAB6225
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human TRIM13 (NP_001007279.1).
Application:IF
Recommended Dilution:IF 1:20 - 1:50
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human TRIM13 (NP_001007279.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILEG SVRN SLWR PAPF KCPT CRKE TSAT GINS LQVN YSLK GIVE KYNK IKIS PKMP VCKG HLGQ PLNI FCLT DMQL ICGI CATR GEHT KHVF CSIE DAYA QERD AFES LFQS FETW RRGD ALSR LDTL ETSK RKSL QLLT KDSD KVKE FFEK LQHT LDQK KNEI LSDF ETMK LAVM QAYD PEIN KLNT ILQE QRMA FNIA EAFK DVSE PIVF LQQM QEFR EKIK VIKE TPLP PSNL PASP LMKN FDTS QWED IKLV DVDK LSLP QDTG TFI
Gene ID:10206
Uniprot:O60858
Cellular Location:Endoplasmic reticulum membrane, Single-pass membrane protein
Calculated MW:19kDa/46kDa/47kDa
Observed MW:
Synonyms:TRIM13, CAR, DLEU5, LEU5, RFP2, RNF77
Background:This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:TRIM13: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligase; Membrane protein, integral; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Tumor suppressor

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: endoplasmic reticulum membrane; cytoplasm; integral to membrane

Molecular Function:protein binding; signal transducer activity; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; negative regulation of viral transcription; ER-associated protein catabolic process; anatomical structure morphogenesis; protein autoubiquitination; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to gamma radiation; innate immune response; signal transduction; positive regulation of macroautophagy; activation of NF-kappaB transcription factor

NCBI Summary:This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O60858
NCBI GenInfo Identifier:71153168
NCBI Gene ID:10206
NCBI Accession:O60858.2
UniProt Secondary Accession:O60858,Q5UBW0, Q5W0U8, Q5W0U9, Q9BQ47, Q9C021, B2RB49
UniProt Related Accession:O60858
Molecular Weight:407
NCBI Full Name:E3 ubiquitin-protein ligase TRIM13
NCBI Synonym Full Names:tripartite motif containing 13
NCBI Official Symbol:TRIM13  
NCBI Official Synonym Symbols:CAR; LEU5; RFP2; DLEU5; RNF77  
NCBI Protein Information:E3 ubiquitin-protein ligase TRIM13; ret finger protein 2; RING finger protein 77; CLL-associated RING finger; tripartite motif protein 13; leukemia-associated protein 5; putative tumor suppressor RFP2; tripartite motif-containing 13; tripartite motif-containing protein 13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5
UniProt Protein Name:E3 ubiquitin-protein ligase TRIM13
UniProt Synonym Protein Names:B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; Putative tumor suppressor RFP2; RING finger protein 77; Ret finger protein 2; Tripartite motif-containing protein 13
Protein Family:Tripartite motif containing
UniProt Gene Name:TRIM13  
UniProt Entry Name:TRI13_HUMAN
Anti-TRIM13 Antibody (CAB6225)Immunofluorescence analysis of HeLa cells using TRIM13 antibody (CAB6225). Blue: DAPI for nuclear staining.

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