AKAP13 Polyclonal Antibody
- SKU:
- CAB7582
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | AKAP13 Polyclonal Antibody |
Product Code: | CAB7582 |
Reactivity: | Human |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:2000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Cellular Location: | Cytoplasm, Membrane, Nucleus |
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human AKAP13 (NP_006729.4). |
Sequence: | MKLNP QQAPL YGDCV VTVLL AEEDK AEDDV VFYLV FLGST LRHCT STRKV SSDTL ETIAP GHDCC ETVKV QLCAS KEGLP VFVVA EEDFH FVQDE AYDAA QFLAT SAGNQ QALNF TRFLD QSGPP SGDVN SLDKK LVLAF RHLKL PTEWN |
Synonyms: | BRX, LBC, p47, HA-3, Ht31, c-lbc, PRKA13, AKAP-13, AKAP-Lbc, ARHGEF13, PROTO-LB, PROTO-LBC |
Calculated MW: | 308kDa |
Observed MW: | Refer to figures |