Anti-SIRP alpha antibody (DM8) Rabbit mAb (HDAB0005)

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DescriptionThe protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Product nameAnti-SIRP alpha antibody (DM8) Rabbit mAb
SynonymsBIT, CD172a, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Quantity100 µL
ShippingBlue Ice
AntigenSIRP alpha
IsotypeRabbit IgG
ApplicationELISA, Flow Cyt, IP, IF
Immunogen substituteRecombinant human SIRP alpha (Glu31-Arg370)(HDPT0009) produced by using human HEK293 cells
PurificationPurified from cell culture supernatant by affinity chromatography
StorageStore at -20°C for 12 months (Avoid repeated freezing and thawing)
UsageResearch use only
Buffer50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative0.1% Procline 300
ReconstitutionReconstitute with deionized water
Application AdviceFlow Cyt  1/100; IP 1/30
Gene ID140885
Molecular Weight55kDa
Assay Genie Related SKUsHDPT0009