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Anti-BCL2L10 Antibody (CAB17068)

SKU:
CAB17068
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129
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Description

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Antibody Name:Anti-BCL2L10 Antibody
Antibody SKU:CAB17068
Antibody Size:20uL, 50 uL
Application:IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 11-140 of human BCL2L10 (NP_065129.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 11-140 of human BCL2L10 (NP_065129.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADP LRER TELL LADY LGYC AREP GTPE PAPS TPEA AVLR SAAA RLRQ IHRS FFSA YLGY PGNR FELV ALMA DSVL SDSP GPTW GRVV TLVT FAGT LLER GPLV TARW KKWG FQPR LKEQ EGDV ARDC QR
Gene ID:10017
Uniprot:Q9HD36
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:BCL2L10, BCL-B, Boo, Diva, bcl2-L-10
Background:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.
UniProt Protein Function:BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; integral to membrane; cytosol

Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
UniProt Code:Q9HD36
NCBI GenInfo Identifier:13898394
NCBI Gene ID:10017
NCBI Accession:AAK48715.1
UniProt Secondary Accession:Q9HD36,Q3SX80, Q52LQ9, Q8TCS9,
UniProt Related Accession:Q9HD36
Molecular Weight:23 kDa
NCBI Full Name:BCLB
NCBI Synonym Full Names:BCL2-like 10 (apoptosis facilitator)
NCBI Official Symbol:BCL2L10  
NCBI Official Synonym Symbols:Boo; Diva; BCL-B; bcl2-L-10  
NCBI Protein Information:bcl-2-like protein 10
UniProt Protein Name:Bcl-2-like protein 10
UniProt Synonym Protein Names:Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B
UniProt Gene Name:BCL2L10  
UniProt Entry Name:B2L10_HUMAN

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