null

Anti-C8G Antibody (CAB17296)

SKU:
CAB17296
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€129 - €259
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-C8G Antibody
Antibody SKU:CAB17296
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human C8G (NP_000597.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human C8G (NP_000597.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLPP GTAT LLTL LLAA GSLG QKPQ RPRR PASP ISTI QPKA NFDA QQFA GTWL LVAV GSAC RFLQ EQGH RAEA TTLH VAPQ GTAM AVST FRKL DGIC WQVR QLYG DTGV LGRF LLQA RDAR GAVH VVVA ETDY QSFA VLYL ERAG QLSV KLYA RSLP VSDS VLSG FEQR VQEA HLTE DQIF YFPK YGFC EAAD QFHV LDEV RR
Gene ID:733
Uniprot:P07360
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:C8C, C8G
Background:The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
UniProt Protein Function:C8G: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: membrane attack complex; extracellular region

Molecular Function:complement binding; protein complex binding; retinol binding

Biological Process: cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

NCBI Summary:The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
UniProt Code:P07360
NCBI GenInfo Identifier:166197660
NCBI Gene ID:733
NCBI Accession:NP_000597.2
UniProt Secondary Accession:P07360,Q14CT8, Q14CU0, Q5SQ07,
UniProt Related Accession:P07360
Molecular Weight:22,277 Da
NCBI Full Name:complement component C8 gamma chain
NCBI Synonym Full Names:complement component 8, gamma polypeptide
NCBI Official Symbol:C8G  
NCBI Official Synonym Symbols:C8C  
NCBI Protein Information:complement component C8 gamma chain
UniProt Protein Name:Complement component C8 gamma chain
Protein Family:Complement component
UniProt Gene Name:C8G  
UniProt Entry Name:CO8G_HUMAN

Related Products