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Anti-CENPQ Antibody (CAB7628)

SKU:
CAB7628
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-CENPQ Antibody CAB7628
  • Cell Biology Antibodies 11 Anti-CENPQ Antibody CAB7628
€139 - €419
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Description

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Antibody Name:Anti-CENPQ Antibody
Antibody SKU:CAB7628
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEDL TNVS SLLN MERA RDKA NEEG LALL QEEI DKMV ETTE LMTG NIQS LKNK IQIL ASEV EEEE ERVK QMHQ INSS GVLS LPEL SQKT LKAP TLQK EILA LIPN QNAL LKDL DILH NSSQ MKSM STFI EEAY KKLD AS
Gene ID:55166
Uniprot:Q7L2Z9
Cellular Location:Chromosome, Nucleus, centromere
Calculated MW:30kDa
Observed MW:31kDa
Synonyms:CENPQ, C6orf139, CENP-Q
Background:
UniProt Protein Function:CENPQ: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: nucleoplasm; cytosol; chromosome, pericentric region; actin cytoskeleton

Biological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle

NCBI Summary:CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
UniProt Code:Q7L2Z9
NCBI GenInfo Identifier:40068061
NCBI Gene ID:55166
NCBI Accession:NP_060602.2
UniProt Secondary Accession:Q7L2Z9,Q6IN61, Q9NVS5, A8KAF1,
UniProt Related Accession:Q7L2Z9
Molecular Weight:30,595 Da
NCBI Full Name:centromere protein Q
NCBI Synonym Full Names:centromere protein Q
NCBI Official Symbol:CENPQ  
NCBI Official Synonym Symbols:CENP-Q; C6orf139  
NCBI Protein Information:centromere protein Q
UniProt Protein Name:Centromere protein Q
Protein Family:Centromere protein
UniProt Gene Name:CENPQ  
UniProt Entry Name:CENPQ_HUMAN
Anti-CENPQ Antibody (CAB7628)Western blot analysis of extracts of Jurkat cells, using CENPQ antibody (CAB7628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CENPQ Antibody (CAB7628)Immunofluorescence analysis of U2OS cells using CENPQ antibody (CAB7628) at dilution of 1:100. Blue: DAPI for nuclear staining.

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