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Anti-DEDD2 Antibody (CAB8281)

SKU:
CAB8281
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
€139 - €419
Frequently bought together:

Description

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Antibody Name:DEDD2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8281
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DEDD2 (NP_579874.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse brain, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DEDD2 (NP_579874.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MALS GSTP APCW EEDE CLDY YGML SLHR MFEV VGGQ LTEC ELEL LAFL LDEA PGAA GGLA RARS GLEL LLEL ERRG QCDE SNLR LLGQ LLRV LARH DLLP HLAR KRRR PVSP ERYS YGTS SSSK RTEG SCRR RRQS SSSA NSQQ GQWE TGSP PTKR QRRS RGRP SGGA RRRR RGAP AAPQ QQSE PARP SSEG KVTC DIRL RVRA EYCE HGPA LEQG VASR RPQA LARQ LDVF GQAT AVLR
Gene ID:162989
Uniprot:Q8WXF8
Cellular Location:Nucleus, nucleolus
Calculated MW:35kDa/36kDa
Observed MW:50kDa
Synonyms:DEDD2, FLAME-3, FLAME3
Background:This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:DEDD2: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleolus; nucleoplasm

Molecular Function:DNA binding; protein binding

Biological Process: apoptotic nuclear changes; induction of apoptosis via death domain receptors

NCBI Summary:This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
UniProt Code:Q8WXF8
NCBI GenInfo Identifier:47116024
NCBI Gene ID:162989
NCBI Accession:Q8WXF8.1
UniProt Secondary Accession:Q8WXF8,Q8NBR2, Q8NES1, Q8TAA8, Q96D35,
UniProt Related Accession:Q8WXF8
Molecular Weight:35,577 Da
NCBI Full Name:DNA-binding death effector domain-containing protein 2
NCBI Synonym Full Names:death effector domain containing 2
NCBI Official Symbol:DEDD2  
NCBI Official Synonym Symbols:FLAME-3  
NCBI Protein Information:DNA-binding death effector domain-containing protein 2
UniProt Protein Name:DNA-binding death effector domain-containing protein 2
UniProt Synonym Protein Names:DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3
Protein Family:DNA-binding death effector domain-containing protein
UniProt Gene Name:DEDD2  
UniProt Entry Name:DEDD2_HUMAN
Anti-DEDD2 Polyclonal Antibody (CAB8281)Western blot analysis of extracts of various cell lines, using DEDD2 antibody (CAB8281) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s.

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