Anti-EME2 Antibody (CAB9891)
- SKU:
- CAB9891
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-EME2 Antibody |
| Antibody SKU: | CAB9891 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EME2 (NP_001244299.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EME2 (NP_001244299.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARV GPGR AGVS CQGR GRGR GGSG QRRP PTWE ISDS DAED SAGS EAAA RARD PAGE RRAA AEAL RLLR PEQV LKRL AVCV DTAI LEDA GADV LMEA LEAL GCEC RIEP QRPA RSLR WTRA SPDP CPRS LPPE VWAA GEQE LLLL LEPE EFLQ GVAT LTQI SGPT HWVP WISP ETTA RPHL AVIG LDAY LWSR QHVS RGTQ QPES PKVA GAEV AVSW PEVE |
| Gene ID: | 197342 |
| Uniprot: | A4GXA9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 26kDa/41kDa |
| Observed MW: | 41kDa |
| Synonyms: | EME2, SLX2B, gs125 |
| Background: |
| UniProt Protein Function: | EME2: Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. Belongs to the EME1/MMS4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Deoxyribonuclease; EC 3.1.22.- Chromosomal Location of Human Ortholog: 16p13.3 |
| NCBI Summary: | EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | A4GXA9 |
| NCBI GenInfo Identifier: | 635377448 |
| NCBI Gene ID: | 197342 |
| NCBI Accession: | A4GXA9.3 |
| UniProt Secondary Accession: | A4GXA9,Q8TEP2, Q96RY3, |
| UniProt Related Accession: | A4GXA9 |
| Molecular Weight: | 26,446 Da |
| NCBI Full Name: | Probable crossover junction endonuclease EME2 |
| NCBI Synonym Full Names: | essential meiotic structure-specific endonuclease subunit 2 |
| NCBI Official Symbol: | EME2Â Â |
| NCBI Official Synonym Symbols: | SLX2B; gs125Â Â |
| NCBI Protein Information: | probable crossover junction endonuclease EME2 |
| UniProt Protein Name: | Probable crossover junction endonuclease EME2 |
| Protein Family: | Probable crossover junction endonuclease |
| UniProt Gene Name: | EME2Â Â |
| UniProt Entry Name: | EME2_HUMAN |
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