GUCA1A Antibody, Biotin conjugated (PACO27264)

SKU:
PACO27264
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Antibody type:
Polyclonal
Conjugation:
Biotin
€279

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:GUCA1A Antibody, Biotin conjugated (PACO27264)
Antibody SKU:PACO27264
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Guanylyl cyclase-activating protein 1 protein (2-201AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Biotin
Background:Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Synonyms:Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A), GUCA1A, C6orf131 GCAP GCAP1 GUCA1
UniProt Protein Function:GUCA1A: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3). COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Molecular Function:calcium ion binding; calcium sensitive guanylate cyclase activator activity; guanylate cyclase regulator activity

Biological Process: positive regulation of guanylate cyclase activity; regulation of rhodopsin mediated signaling

Disease: Cone Dystrophy 3

NCBI Summary:This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:P43080
NCBI GenInfo Identifier:46577585
NCBI Gene ID:2978
NCBI Accession:P43080.3
UniProt Secondary Accession:P43080,Q7Z6T1, Q9NU14, B3KWT4,
UniProt Related Accession:P43080
Molecular Weight:22,920 Da
NCBI Full Name:Guanylyl cyclase-activating protein 1
NCBI Synonym Full Names:guanylate cyclase activator 1A
NCBI Official Symbol:GUCA1A  
NCBI Official Synonym Symbols:COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131  
NCBI Protein Information:guanylyl cyclase-activating protein 1
UniProt Protein Name:Guanylyl cyclase-activating protein 1
UniProt Synonym Protein Names:Guanylate cyclase activator 1A
Protein Family:Guanylyl cyclase-activating protein
UniProt Gene Name:GUCA1A  
UniProt Entry Name:GUC1A_HUMAN

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