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Anti-HPR Antibody (CAB9898)

SKU:
CAB9898
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 12 Anti-HPR Antibody CAB9898
  • Cell Biology Antibodies 12 Anti-HPR Antibody CAB9898
  • Cell Biology Antibodies 12 Anti-HPR Antibody CAB9898
€139 - €419
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Description

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Antibody Name:Anti-HPR Antibody
Antibody SKU:CAB9898
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-348 of human HPR (NP_066275.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:HepG2, HL-60, BT-474, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-348 of human HPR (NP_066275.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LYSG NDVT DISD DRFP KPPE IANG YVEH LFRY QCKN YYRL RTEG DGVY TLND KKQW INKA VGDK LPEC EAVC GKPK NPAN PVQR ILGG HLDA KGSF PWQA KMVS HHNL TTGA TLIN EQWL LTTA KNLF LNHS ENAT AKDI APTL TLYV GKKQ LVEI EKVV LHPN YHQV DIGL IKLK QKVL VNER VMPI CLPS KNYA EVGR VGYV SGWG QSDN FKLT DHLK YVML PVAD QYDC ITHY EGST CPKW KAPK SPVG VQPI LNEH TFCV GMSK YQED TCYG DAGS AFAV HDLE EDTW YAAG ILSF DKSC AVAE YGVY VKVT SIQH WVQK TIAE N
Gene ID:3250
Uniprot:P00739
Cellular Location:Secreted
Calculated MW:39kDa/43kDa
Observed MW:39kDa
Synonyms:HPR, A-259H10.2, HP
Background:This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer.
UniProt Protein Function:HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region

Biological Process: positive regulation of defense response to virus by host; receptor-mediated endocytosis

NCBI Summary:This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
UniProt Code:P00739
NCBI GenInfo Identifier:262527547
NCBI Gene ID:3250
NCBI Accession:P00739.2
UniProt Secondary Accession:P00739,Q7LE20, Q92658, Q92659, Q9ULB0,
UniProt Related Accession:P00739
Molecular Weight:43,078 Da
NCBI Full Name:Haptoglobin-related protein
NCBI Synonym Full Names:haptoglobin-related protein
NCBI Official Symbol:HPR  
NCBI Official Synonym Symbols:HP; A-259H10.2  
NCBI Protein Information:haptoglobin-related protein
UniProt Protein Name:Haptoglobin-related protein
Protein Family:HPr-like protein
UniProt Gene Name:HPR  
UniProt Entry Name:HPTR_HUMAN
Anti-HPR Polyclonal Antibody (CAB9898)Western blot analysis of extracts of various cell lines, using HPR antibody (CAB9898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
Anti-HPR Polyclonal Antibody (CAB9898)Immunohistochemistry of paraffin-embedded mouse lung using HPR antibody (CAB9898) at dilution of 1:100 (40x lens).
Anti-HPR Polyclonal Antibody (CAB9898)Immunohistochemistry of paraffin-embedded human prostate using HPR antibody (CAB9898) at dilution of 1:100 (40x lens).

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