| UniProt Protein Function: | ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 2p25.2 Cellular Component: cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle Molecular Function:GDP-dissociation inhibitor activity; integrin binding; protein binding; protein complex binding; protein transporter activity Biological Process: activation of protein kinase B; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell migration; cell-matrix adhesion; integrin activation; integrin-mediated signaling pathway; lumen formation; myoblast migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; negative regulation of protein binding; negative regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of Notch signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; protein transport; receptor clustering; regulation of blood vessel size; regulation of cell adhesion mediated by integrin; regulation of GTPase activity; substrate-bound cell migration, cell release from substrate |
| NCBI Summary: | The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | O14713 |
| NCBI GenInfo Identifier: | 17366148 |
| NCBI Gene ID: | 9270 |
| NCBI Accession: | O14713.1 |
| UniProt Secondary Accession: | O14713,O14714, Q53RS0, D6W4Y9, |
| UniProt Related Accession: | O14713 |
| Molecular Weight: | 16,140 Da |
| NCBI Full Name: | Integrin beta-1-binding protein 1 |
| NCBI Synonym Full Names: | integrin subunit beta 1 binding protein 1 |
| NCBI Official Symbol: | ITGB1BP1Â Â |
| NCBI Official Synonym Symbols: | ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha  |
| NCBI Protein Information: | integrin beta-1-binding protein 1 |
| UniProt Protein Name: | Integrin beta-1-binding protein 1 |
| UniProt Synonym Protein Names: | Integrin cytoplasmic domain-associated protein 1; ICAP-1 |
| Protein Family: | Integrin beta-1-binding protein |
| UniProt Gene Name: | ITGB1BP1Â Â |
| UniProt Entry Name: | ITBP1_HUMAN |
