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Anti-KCNK1 Antibody (CAB12835)

SKU:
CAB12835
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-KCNK1 Antibody CAB12835
  • Signal Transduction Antibodies 1 Anti-KCNK1 Antibody CAB12835
  • Signal Transduction Antibodies 1 Anti-KCNK1 Antibody CAB12835
  • Signal Transduction Antibodies 1 Anti-KCNK1 Antibody CAB12835
€139 - €419
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Description

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Antibody Name:Anti-KCNK1 Antibody
Antibody SKU:CAB12835
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 267-336 of human KCNK1 (NP_002236.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-549, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 267-336 of human KCNK1 (NP_002236.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FCEL HELK KFRK MFYV KKDK DEDQ VHII EHDQ LSFS SITD QAAG MKED QKQN EPFV ATQS SACV DGPA NH
Gene ID:3775
Uniprot:O00180
Cellular Location:Apical cell membrane, Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Multi-pass membrane protein, Perikaryon, Recycling endosome, dendrite, synapse
Calculated MW:38kDa
Observed MW:38kDa
Synonyms:KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1
Background:This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.
UniProt Protein Function:KCNK1: Weakly inward rectifying potassium channel. Homodimer (Potential). Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; voltage-gated potassium channel complex

Molecular Function:inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; sodium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; regulation of resting membrane potential

NCBI Summary:This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
UniProt Code:O00180
NCBI GenInfo Identifier:13124036
NCBI Gene ID:3775
NCBI Accession:O00180.1
UniProt Secondary Accession:O00180,Q13307, Q5T5E8,
UniProt Related Accession:O00180
Molecular Weight:
NCBI Full Name:Potassium channel subfamily K member 1
NCBI Synonym Full Names:potassium two pore domain channel subfamily K member 1
NCBI Official Symbol:KCNK1  
NCBI Official Synonym Symbols:DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1  
NCBI Protein Information:potassium channel subfamily K member 1
UniProt Protein Name:Potassium channel subfamily K member 1
UniProt Synonym Protein Names:Inward rectifying potassium channel protein TWIK-1
Protein Family:Potassium channel subfamily
UniProt Gene Name:KCNK1  
Anti-KCNK1 Antibody (CAB12835)Western blot analysis of extracts of various cell lines, using KCNK1 antibody (CAB12835) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-KCNK1 Antibody (CAB12835)Immunohistochemistry of paraffin-embedded rat heart using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens).
Anti-KCNK1 Antibody (CAB12835)Immunohistochemistry of paraffin-embedded mouse lung using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens).
Anti-KCNK1 Antibody (CAB12835)Immunohistochemistry of paraffin-embedded mouse heart using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens).

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